After long hours at Reina Sofia museum time for going to Outer Space. It's called NuBel and it makes you wonderfully dizzy. Or, better, go there just before the museum - drink some wine and go to admire Guernica in 3D.
Medialab Prado is the coolest place to work, to collaborate, to do workshops, to participate in events and conferences. They are the nicest people in the planet doing such interesting programs. My favorite is Interactivos. It is also a good place to meet new friends and go afterwards for beers in the bars around Lavapies, a district full of art galleries and Museums.