The city’s old slaughterhouse, now an art centre. It’s a monumental project that somehow manages to survive the financial crisis. They organize interesting exhibitions, talks and other activities. The perfect excuse to go for a walk around the southern side of Madrid.
Matadero is a contemporary creation center, a charming place to go at night to see the concerts and architectural lights. It always has an interesting program going on.
Reina Sofia museum is always a good idea. And it's never enough of Picasso's Guernica as well as the other modern art gems. Save some hours for visiting and then look round the corner and have some wine at NuBel.
Medialab Prado is the coolest place to work, to collaborate, to do workshops, to participate in events and conferences. They are the nicest people in the planet doing such interesting programs. My favorite is Interactivos. It is also a good place to meet new friends and go afterwards for beers in the bars around Lavapies, a district full of art galleries and Museums.