The Frank Stella’s are the best. They are all over the city and they always look amazing. Two of my favorites are the Saatchi and Saatchi lobby (pictured) and the Citi Corp building in Midtown.
As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.
I love enjoying some Amazing Vietnamese food at this place before heading out to the different bars around Jefferson on L. The restaurant is just behind Elsewhere so you have a nice mix of things to do if you start your night here.