Located near to the Alamo square's Painted Ladies is this wonderful gothic "stick" Italian villa with a long weirde history. Built by a Candy Baron in 1889, it's housed variously; a Russian Czarist nightclub, Jazz musicians, Satanists, a Manson family member, and one of the first 60's Hippy communes -Calliope. Creepy as hell enshrouded in fog after dark.
If you can get past the bourgie factor and/or you work down the street like I do, you will come to love this place. It has some of the best food in the city, a Blue Bottle coffee, and an observation deck from which you can watch the ferries come and go, emitting their weird beeps and disgorging tourists. The people who work here are great too (whether or not I dated a baker from the Acme Bread kiosk because of a Craigslist missed connection will be left to history).
In the Mission, now as terminally hip as it was formally poor, the St Francis is a greasy good time since 1918. Stuck beautifully in the 50's both aesthetically and menu wise it's Americana in a bun. Dig in.
Shopping area in Japantown connected by an outdoor plaza with a Japanese Pagoda. The malls feature some good food spots and as well as Kinokuniya Bookstore.