A veteran San Francisco arts institution that recently moved from its home in the Mission to the bottom of the San Francisco Chronicle Building. Their gallery regularly puts on exhibitions that are relevant, accessible, and often straight up delightful. As opposed to some of the more buttoned-up galleries, Intersection’s penchant for participatory pieces is met with a regular crowd that tends to be game for participating, which always makes for a good time.
Located near to the Alamo square's Painted Ladies is this wonderful gothic "stick" Italian villa with a long weirde history. Built by a Candy Baron in 1889, it's housed variously; a Russian Czarist nightclub, Jazz musicians, Satanists, a Manson family member, and one of the first 60's Hippy communes -Calliope. Creepy as hell enshrouded in fog after dark.
You have a lot of hills to choose from in San Francisco but in my opinion the best (and most varied) views are from Bernal Hill. Bonus: from my kitchen table I can watch tiny blobs moving around on this hill-- slow blobs are people, fast blobs are dogs.
If you can get past the bourgie factor and/or you work down the street like I do, you will come to love this place. It has some of the best food in the city, a Blue Bottle coffee, and an observation deck from which you can watch the ferries come and go, emitting their weird beeps and disgorging tourists. The people who work here are great too (whether or not I dated a baker from the Acme Bread kiosk because of a Craigslist missed connection will be left to history).