Kw is a great art institute situated at the backyard of a very eastern part of town, place for many other small galleries. Auguststrasse is worth the walk and Kw is worth the stop.
Chalet is one of many clubs in Berlin. It's a very interesting option if you want to know what Berlins night can be. Music is great and environment too. It 's a decadent building in the inside with curious corners...
A very good reason to travel West: the C/O, next to the formerly infamous Berliner Zoo tube station, is an awesome museum dedicated to photography and visual media. Previous exhibitions include Larry Clark, Martin Parr, Anton Corbijn, Annie Leibovitz and Stephen Shore.