I live above TriBeCa and take walks into and around this area often. It's quiet, usually on the emptier side, and hosts a few gems of restaurants including Tiny's, Takahachi, and Odeon - all on the same block of West Broadway.
The naked baby dolls piled up in the front window of SEARCH & DESTROY is a good preview for what you’re in for. If you’re looking for something weird, this East Village shop is a good starting point. In addition to vintage clothing with a seriously punk rock lean, they also sell everything from sex toys to Manic Panic hair dye.
It's Christmas year-round at Panna II, as the walls and ceilings are completely covered with festive string lights. A great restaurant for a group dinner, Panna II offers small sharable plates in a fun and lively atmosphere. It's BYOB with no corkage fee so stop by the liquor store beforehand to pick up all the wine, beer and liquor you can carry.