I live above TriBeCa and take walks into and around this area often. It's quiet, usually on the emptier side, and hosts a few gems of restaurants including Tiny's, Takahachi, and Odeon - all on the same block of West Broadway.
The Bronx Botanical Garden is a place my father and I have been going to since I was a child. Here's a photograph I took of him here. It has hundreds of species of trees and flowers. Sitting in the middle of the Bronx, it's most recognizable as a green oasis from the grays and concrete of city life.