Favorite italian restaurant, great simple food, friendly staff and the coolest atmosphere (vinil music only). Smart to make a reservation before you go.
A very good reason to travel West: the C/O, next to the formerly infamous Berliner Zoo tube station, is an awesome museum dedicated to photography and visual media. Previous exhibitions include Larry Clark, Martin Parr, Anton Corbijn, Annie Leibovitz and Stephen Shore.
Kw is a great art institute situated at the backyard of a very eastern part of town, place for many other small galleries. Auguststrasse is worth the walk and Kw is worth the stop.
If you like fashion then this is the place to be. The label was founded in 2005 by Nando and Silvia, two spanish designers. I like this place because I love the wool coats and the patterns they create. They support local industry and that is a top of the top for me.