I probably frequent here twice a week, because I am obsessed with Mexican food, and I'm fortunate enough to live in close proximity to this place. Taqueria Tepango is definitely a sapphire in the rough since there are a lot of terrible/over-priced Mexican restaurants in NYC.
The reputation of Mission Chinese Food is for being cool, weird, and extremely eccentric, which tends to mean that you either love it or hate it (an assessment that is at least somewhat correlated to your personal tolerance for spice).
Yossi Milo is, in my opinion, the most dynamic and eclectic of the photography galleries in NYC. From portaiture to architecture to experimental digital sculptural giant animals to street photography, they show an endlessly exciting range of work. Some of my favorite recent shows include Simen Johan's mythical beasts, Ezra Stoller's architectural photographs of the TWA terminal, and Sze Tsung Leong's huge cityscapes.
The naked baby dolls piled up in the front window of SEARCH & DESTROY is a good preview for what you’re in for. If you’re looking for something weird, this East Village shop is a good starting point. In addition to vintage clothing with a seriously punk rock lean, they also sell everything from sex toys to Manic Panic hair dye.