The operators of the Peter Pan bakery make the best donuts I've ever tasted. This place is charming to its core. Decor and presentation: circa 1971 & virtually unchanged since.
I love having Breakfast at Le Coucou - you'll find me here several times a week. Le Californien, OJ and Expresso! Dinner is very formal - but amazing if you dig the French high-end, but Pro tip: They have amazing drinks, so drop by and hang in the bar for a few drinks!
As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.