The Home Depot is one of the first things I saw when the taxi brought me at the place where I live now in NYC. I am renting a room in an old feather factory, which the owner build into a very cozy loft with rooms, common places and studios over the last 12 years. The Home Depot is a massive construction store, one of the leading ones in the US if you can say something like that about construction stores...You ll find them everywhere in the states as well as in my backyard and you can even follow them on Facebook. In general everybody in Bed Stuy complains about the Home Depot, because the employees are grumpy, lazy and never know anything when you ask them for something.
I live above TriBeCa and take walks into and around this area often. It's quiet, usually on the emptier side, and hosts a few gems of restaurants including Tiny's, Takahachi, and Odeon - all on the same block of West Broadway.
Luhring Augustine did a good job of converting an old warehouse/storage facility into a blue chip commercial art gallery that stages four shows of contemporary art per year. Which means you can catch museum quality shows in an unlikely spot, away from all the Chelsea pomp, and it actually has friendly staff, instead of a cold gallerina sat behind a desk pretending to be on the phone.