I live above TriBeCa and take walks into and around this area often. It's quiet, usually on the emptier side, and hosts a few gems of restaurants including Tiny's, Takahachi, and Odeon - all on the same block of West Broadway.
Mekelburg's is equal parts hipster bodega, bar and sandwich haven. I always go for the cheese counter, the babka and the late night fried chicken sandwich, which is hands down one of the best I've had in NY.