As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.
Local fashion (men/unisex) with beautiful signature varsity jackets. Also exhibits interesting artists in the same space. They say they want to tell the story of style throughout American history and to emphasize the power of presentation and they do this extremely well.
Housing European Romanesque and Gothic collections, the building itself sits high on a hill offering far reaching views over the Hudson River and Upper Manhattan. A place to bookmark for after the Spring equinox when you can ramble amongst the fragrant herb gardens of Fort Tryon Park and drink in the air of the season.
I don't go to the movies much but when I do I love coming here... they have the best of the independent and international films and it's the last of it's kind in New York.