To have the best lunches like a 'fried peanut butter sandwich', lounge or book a room for a few days in the heart of the city, visit 'The Ace Hotel'. Ease down in the couches, order a Brooklyn Beer and relax. A great place to meet up.
As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.
A Gallery, A Cafe, A Shop, A Fashion brand, A Bar. This is the Boreum Hill version of Maison Kitsunes many places where they blend Music, fashion, Art, and food. Many times something interesting to see and just a beautiful space.