I live above TriBeCa and take walks into and around this area often. It's quiet, usually on the emptier side, and hosts a few gems of restaurants including Tiny's, Takahachi, and Odeon - all on the same block of West Broadway.
I remember when I saw Shadows, by Andy Warhol in that big room. I was sitting in a sofa, and felt asleep. When I woke up it felt incredible. When my friends come to visit me it's a place where I like to go all together.
Manhattan's Chinatown is my second favorite neighborhood next to Fort Greene. It's full of people, odors, bars, clubs, cafes, and restaurants. There's always something going on here.