This is a hot spot for plant enthusiasts. A recurring L.A. pop-up where the employees can tell you as much or as little as you want to know about cacti. Marco can tell you about the trees. Must visit, but only open April/May - September/October.
As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.
Best pizza in NY. Be prepared to wait. Check to see if they are shut down by the health department or tax collectors before going. Get the square pie with pepperoni and hot peppers.