As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.
Being on the ground floor of the building I work in, this Japanese outpost serves as my everything store. I appreciate their minimalist aesthetic coupled with their modest pricing.
My favorite Chinese food spot. The best Peking duck! Ignore the C health code rating in the window, they must have made a mistake ;) Also, It's BYOB with no uncorking fee, go crazy.
Andrew Tarlow's Diner is a neighborhood institution and pioneer of gratuity-free establishments in Brooklyn. This place serves up breakfast, lunch and dinner in an old converted dining car under the Williamsburg bridge. A seasonal menu of fresh, New American style food that changes daily.
The best part of the new Whitney Museum is the view in all directions from the terrace - and also from the staircase facing West. I'm afraid it upstages the Art.