As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.
Mekelburg's is equal parts hipster bodega, bar and sandwich haven. I always go for the cheese counter, the babka and the late night fried chicken sandwich, which is hands down one of the best I've had in NY.
If I lived closer to the West Village I’d go over to Jack’s every morning for a coffee and occasionally having what is probably the best chocolate chip cookie in New York (and it’s just a dollar!). Even though it’s rarely in my way I try to go here now and then, maybe in combination with a stroll down the beautiful Bleeker Street or to read a book sitting in their window.