I love that there's a museum dedicated to American art, founded at a time when American artists were underappreciated. The exhibitions are curated with a broad but discerning eye, and the architecture is spectacular. In my experience it's typically much quieter than the obvious choices like the Met and the MoMA - although both are remarkable, there's something I love about the scale and style of the Whitney.
Being on the ground floor of the building I work in, this Japanese outpost serves as my everything store. I appreciate their minimalist aesthetic coupled with their modest pricing.
One of the last untapped areas of downtown Manhattan. Hand pulled noodles, cheap eats, and a concentrated area of families make this an often interesting place to explore.