Death & Co is my favorite place for delicious cocktails and small bites. Their truffle mac and cheese and lobster rolls are delicious and love just about every drink on their whisky menu.
The reputation of Mission Chinese Food is for being cool, weird, and extremely eccentric, which tends to mean that you either love it or hate it (an assessment that is at least somewhat correlated to your personal tolerance for spice).
Chavela's makes delicious authentic Mexican food and its around the corner from my house, so I come here a lot. They make a mean margarita, and you can't beat their happy hour prices. $2 tacos? Yes, please. The decor is bright and lively, and the bar is made of beautiful Mexican tiles.