The reputation of Mission Chinese Food is for being cool, weird, and extremely eccentric, which tends to mean that you either love it or hate it (an assessment that is at least somewhat correlated to your personal tolerance for spice).
I love this excellent independent arthouse theater in the Lower East side. Metrograph projects archive quality 35mm and independent films. Tastefully decorated, there is also a candy store, bookstore and restaurant.
Little skips is my place when I need to refill my energy with some morning sunlight. The big windows facing the street let all the light in while you can drink some coffee.
My favorite thing to eat is the grilled cheese sandwich with some avocado. Out of rush hours or weekend mornings, it's a pretty good space to take your laptop and get some work done.
I love that there's a museum dedicated to American art, founded at a time when American artists were underappreciated. The exhibitions are curated with a broad but discerning eye, and the architecture is spectacular. In my experience it's typically much quieter than the obvious choices like the Met and the MoMA - although both are remarkable, there's something I love about the scale and style of the Whitney.