City Island is a seaside town in the Bronx. Known for its fishing, seafood, and main street it is a self-contained working-class haven. The buildings range from late 1800's houses to 1960's storefronts, and you can smell the ocean everywhere on the island. Restaurants and local pubs dot City Island Ave, and even the few empty storefronts stay vibrant.
The Frank Stella's are the best. They are all over the city and they always look amazing. Two of my favorites are the Saatchi and Saatchi lobby (pictured) and the Citi Corp building in Midtown.
As Jim Jarmusch put it in the documentary Blank City, the address is roughly between Bowery, Avenue B, 14th Street and Houston. This area of the city is steeped in art, film, and music history; so many hugely influential artists, film makers, and musicians still live and work here. For such a small area, I think it's had more concentrated influence on contemporary art and culture than anywhere else.