I live above TriBeCa and take walks into and around this area often. It's quiet, usually on the emptier side, and hosts a few gems of restaurants including Tiny's, Takahachi, and Odeon - all on the same block of West Broadway.
For the first time in Manhattan we lived on 14th street – this nice and cozy café around the corner (on 16th) still is our favorite place for delicious breakfast or brunch... Think they have tons of meals on their menu, quite affordable for huge portions.. Plus, good music.
Nothing is more quintessentially New York than a diner. This eatery not only serves excellent, traditional diner fare, but does so in an eclectic environment that mixes Baroque decadence with Midtown grit.